Factory Supply Pharmaceutical Raw Material High Quality Indapamide 99%
1. Indapamide is a thiazide-like diuretic drug marketed by Servier, generally used in the treatment of hypertension, as well as decompensated heart failure. Combination preparations with perindopril (an ACE inhibitor antihypertensive) are also available.Indapamide powder
2. White needle crystal or crystalline powder, odorless, tasteless. It is almost insoluble in water or dilute hydrochloric acid, while it can be dissolved in ethanol or ethyl acetate, and it is soluble in acetone, acetic acid, slightly soluble in chloroform or ether.
3. Indapamide is currently the most popular non-prescription diuretic
antihypertensive drug with good efficacy, stable blood pressure, fewer
side effects, etc.
1. Indapamide have diuretic and calcium antagonist dual effect by
inhibiting the proximal end of the distal convoluted tubule Na+
reabsorption, resulting in diuresis, while by blocking Ca2+ influx
especially a higher selectivity for vascular smooth muscle to dilate the
small blood vessels of the outer periphery, resulting in
antihypertensive effect. But the effect to vascular smooth muscle is
stronger than the diuretic effect.
2. It can lower blood pressure with lower dose compared to diuretic effect. Higher dose will display diuretic effect. But there is no disadvantage compared to thiazide diuretics, that it does not cause orthostatic hypotension, flushing and reflex tachycardia, nor blood lipids, glucose metabolism and renal function.
Indapamide Application
1. This medication is used to treat high blood pressure. Indapamide is
also used to reduce extra salt and fluid in the body (edema) caused by a
certain heart problem (congestive heart failure). Lowering high blood
pressure helps prevent strokes, heart attacks, and kidney problems.
Decreasing extra salt and fluid in the body helps to decrease swelling
and breathing problems from congestive heart failure and increases your
ability to exercise.
2. Indapamide is a “water pill” (diuretic) that increases the amount of urine you make. Getting rid of extra water and salt may help to relax the blood vessels so that bloodcan flow more easily. These effects help to lower blood pressure and decrease the amount of work the heart must do to pump blood.
