Melanotan Hot Sell China Supply PT-141/PT141 Powder Uses Effect on Sexual
PT 141 Powder
(Bremelanotide) is a highly potent synthetic peptide analogue of α-MSH
that may elicit aphrodisiac effects through stimulation of melanocortin
receptors. PT-141 (Bremelanotide) consists of seven amino acids and is a
cyclic, shortened lactam variant of alpha-Melanocyte-stimulating
hormone (α-MSH), a multifunctional peptide that regulates a broad array
of physiological functions. In studies, bremelanotide was shown to
induce lordosis in an animal model and was also effective in treating
sexual dysfunction in both men (erectile dysfunction or impotence) and
women (sexual arousal disorder).
Specification:
Name: PT-141
Synonyms: Bremelanotide, PT-141 Acetate
CAS #: 189691-06-3
Molecular Formula: C50H68N14O10
Molecular Mass: 1025.2 Da (g/mol)
Amino Acid Sequence: Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys">-OH
Function & Usage:
Bremelanotide, similarly to its analogues α-MSH and melanotan II, acts
as a non-selective agonist of all of the melanocortin receptors except
MC2, where it lacks significant affinity. Reported activity of the drug
is as follows:
Bremelanotide appears to stimulate sexual desire and arousal completely or mostly via activation of the MC4 receptor (the MC3 receptor may also be involved). It modulates inflammation and limits ischemia via activation of the MC1 and MC4 receptors.
According to Palatin Technologies' original 2003 patent for bremelanotide, it possesses approximately 50 times the potency of melanotan II as an inducer of erection in male rats. In addition, it was stated in the patent that the therapeutic window of bremelanotide in animals (specifically, the range of induction of the desired sexual arousal relative to the induction of side effects including nausea, yawning, stretching, and decreased appetite) was >1,000-fold, whereas that of melanotan II was only 3- to 4-fold. They concluded that bremelanotide would be more tolerable than melanotan II.
