Administer orally without regard to food.1 Administration with meals may
result in looser stools.If patient cannot swallow whole tablet, crush
tablet and mix in applesauce and administer orally or disperse tablet in
water and administer orally or via a nasogastric or gastric feeding
tube.1 Use these mixtures immediately; do not store for later use.1
Administration in other soft foods or liquids not studied.Plecanatide powder
If a dose is missed, do not double the dose.1 Administer the next dose at the regularly scheduled time.
Oral Administration in Applesauce
Crush 3-mg tablet to a powder and mix with 1 teaspoonful of room-temperature applesauce.1 Administer entire mixture immediately.
Oral Administration as Aqueous Dispersion
Place 3-mg tablet in a cup, add approximately 30 mL of room-temperature
water, gently swirl for ≥10 seconds to disperse the disintegrating
tablet, then administer immediately.
Disperse any residue remaining in the cup in an additional 30 mL of
water, gently swirl for ≥10 seconds, then administer immediately.
Administration via Nasogastric or Gastric Tube
Place 3-mg tablet in a cup, add approximately 30 mL of room-temperature
water, gently swirl for ≥15 seconds to disperse the disintegrating
tablet.1 Flush the nasogastric or gastric feeding tube with 30 mL of
water, then draw up entire contents of the plecanatide dispersion into a
syringe and administer immediately.
Disperse any residue remaining in the cup in an additional 30 mL of
water, gently swirl for ≥15 seconds, and administer using the same
syringe.1 Then use the same syringe or a new syringe to flush the
nasogastric or gastric feeding tube with ≥10 mL of water.
