sermorelin acetate (sermorelin) drug
Sermorelin powder
acetate (sermorelin) is the acetate salt of an amidated synthetic 29-
amino acid peptide (GRF 1-29 NH 2 ) that corresponds to the
amino-terminal segment of the naturally occurring human growth
hormone-releasing hormone (GHRH or GRF) consisting of 44 amino acid
residues. The structural formula for sermorelin acetate is:
The free base of sermorelin has the empirical formula C 149 H 246 N 44 O 42 S and a molecular weight of 3,358 daltons.
Sermorelin is a sterile, non-pyrogenic, lyophilized powder intended for
subcutaneous injection after reconstitution with Sodium Chloride
Injection, USP. The reconstituted solution has a pH of 5.0 to 5.5.
Sermorelin is available in vials. The quantitative composition per vial is:
0.5 mg vial: Each vial contains 0.5 mg sermorelin (as the acetate) and 5
mg mannitol. The pH is adjusted with dibasic sodium phosphate and
monobasic sodium phosphate buffer.
3.0 mg vial: Each vial contains 3.0 mg sermorelin (as the acetate) and 5
mg mannitol. The pH is adjusted with dibasic sodium phosphate and
monobasic sodium phosphate buffer.
Sermorelin is approved for diagnostic evaluation of pituitary function
and also for increasing growth in children. Off label usage may include
acute or age-related growth hormone insufficiency
DOSAGE AND ADMINISTRATION
A dosage of 0.2 - 0.3 mcg once daily at bedtime by subcutaneous
injection is recommended. It is also recommended that subcutaneous
injection sites be periodically rotated.
To prevent possible contamination, wipe the rubber vial stopper with an
antiseptic solution before puncturing it with the needle. It is
recommended that Sermorelin be administered using sterile, disposable
syringes and needles. The syringes should be of small enough volume that
the prescribed dose can be drawn from the vial with reasonable
accuracy.
To reconstitute Sermorelin, inject the diluent into the vial of
Sermorelin aiming the liquid against the glass vial wall. Swirl the vial
with a GENTLE rotary motion until contents are dissolved completely. Do
not administer Sermorelin if particles are visible in the reconstituted
solution or if the reconstituted solution is cloudy.
