Raloxifene hydrochloride is the second generation of selective estrogen
receptor modulators (SERM) for the benzothiophene series. The drug is
similar to tamoxifen and exhibits estrogen receptor antagonist
(blocking) properties in some tissues as an estrogen receptor agonist
(activator) in other tissues.Raloxifene powder
The major change between these two agents is their tissue selectivity.
Although raloxifene hydrochloride is a strong antiestrogen in the
mammary gland and uterine tissue, it appears to be estrogen in the
bones. This allows it to protect bone density and mimic the beneficial
effects of endogenous estradiol. This is quite different from tamoxifen,
tamoxifen in the breast and bone are anti-estrogen effect.
In the fight against estrogen, raloxifene hydrochloride has been
approved by the FDA for the prevention and treatment of postmenopausal
women with osteoporosis. Other potential uses are being studied,
including treatment and prevention of cardiovascular disease, breast
cancer, men's breast development, prostate cancer, acromegaly and
uterine cancer.
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