White Lyophilized Powder n acetyl selank peptide 5mg 10mg 2mg selank
Selank powder,
which was developed in Russia, is a short peptide with nootropic and
anxiolytic properties. It is a synthetic analogue of naturally occurring
Tuftsin, an immunomodulatory peptide that modulates IL-6, T helper
cells, monoamine neurotransmitters, and brain-derived neurotropic factor
(BDNF). In fact, Selank and Tuftsin are essentially the same except
that Selank has an additional four amino acids in its chain that help to
improve metabolic stability and half-life.
Selank has been tested in clinical trials as a potential treatment for generalized anxiety disorder.
Selank Anxiety Effects Based on Genes Related to GABA Neurotransmitter
According to Dr. Anastasiya Volkova of the Institute of Molecular
Genetics in Russia, “numerous clinical studies have shown that Selank
has strong antianxiety and neuroprotective effects in the treatment of
anxiety. The clinical effects of Selank are similar to those of the
classical antianxiety medications such as benzodiazepine, which are
allosteric modulators of GABAA receptors and increase the inhibitory
action of GABA.” Selank’s effects include reducing anxiety, improving
mood, lower stress levels, and positively influencing memory and
learning. Like benzodiazepines, low doses of Selank have a sedating
effect. Unlike benzodiazepines, Selank does not appear to be
habit-forming and does not lead to symptoms of withdrawal or amnesia.
Research in rats shows that of the 84 genes known to be connected to
GABA signaling in some way, seven are heavily modulated by Selank and 45
show some change in expression when the peptide is administered.
Overall, 52 genes related to GABA signaling are affected by Selank to
some degree. These results indicate that Selank can directly influence
the expression of genes in nerve cells and that it likely produces
effects by changing the affinity of the GABA receptor for GABA[1].
This alteration of receptor affinity likely explains why Selank is
synergistic with benzodiazepines and other GABA receptor agonists.
Selank and the Immune System in Anxiety
Research in patients with depression indicates that Selank can suppress
the gene responsible for the production of the inflammatory cytokine
IL-6. Interestingly, this effect is only seen in patients with
depression and does not appear to take place in healthy individuals[5].
This suggests that Selank may be useful in treating people with
anxiety-asthenic disorders, severe disorders in which anxiety is
associated with fatigue, headache, heart palpitations, high blood
pressure, nerve pain, and depression.
When comparing Selank to standard anxiolytic treatments, like
benzodiazepines, the two treatments show similar benefits in reducing
anxiety, but only Selank has any effect on asthenic symptoms like
fatigue and pain[6]. Part of the effect is likely due to Selank’s
ability to modulated IL-6 expression while part is likely due to the
peptide’s ability to alter the rate of breakdown of the body’s natural
pain killers, enkephalins.
Testing of Selank in rats has revealed that the peptide regulates the
expression of some 34 genes involved in the inflammatory process. These
genes affect chemokines, cytokines, and receptors for both. In
particular, Selank has been found to alter expression of BcI6, a gene
that is heavily involved in the development of the immune system[7].
This study, more than any other, revealed that Selank has very complex
biological effects, but may help to deepen our understanding of how the
immune system develops.
Selank and even fragments of Selank have been shown to temporarily alter
gene expression for C3, CAsp1, Il2rf, and Xcr1 in the mouse spleen. By
affecting these genes, Selank is able to alter the balance of the immune
system and thereby modulate inflammation[8].This alteration of receptor
affinity likely explains why Selank is synergistic with benzodiazepines
and other GABA receptor agonists.
Selank and the Immune System in Anxiety
Research in patients with depression indicates that Selank can suppress
the gene responsible for the production of the inflammatory cytokine
IL-6. Interestingly, this effect is only seen in patients with
depression and does not appear to take place in healthy individuals[5].
This suggests that Selank may be useful in treating people with
anxiety-asthenic disorders, severe disorders in which anxiety is
associated with fatigue, headache, heart palpitations, high blood
pressure, nerve pain, and depression.
When comparing Selank to standard anxiolytic treatments, like
benzodiazepines, the two treatments show similar benefits in reducing
anxiety, but only Selank has any effect on asthenic symptoms like
fatigue and pain[6]. Part of the effect is likely due to Selank’s
ability to modulated IL-6 expression while part is likely due to the
peptide’s ability to alter the rate of breakdown of the body’s natural
pain killers, enkephalins.
Testing of Selank in rats has revealed that the peptide regulates the
expression of some 34 genes involved in the inflammatory process. These
genes affect chemokines, cytokines, and receptors for both. In
particular, Selank has been found to alter expression of BcI6, a gene
that is heavily involved in the development of the immune system[7].
This study, more than any other, revealed that Selank has very complex
biological effects, but may help to deepen our understanding of how the
immune system develops.
Selank and even fragments of Selank have been shown to temporarily alter
gene expression for C3, CAsp1, Il2rf, and Xcr1 in the mouse spleen. By
affecting these genes, Selank is able to alter the balance of the immune
system and thereby modulate inflammation[8].
