Product: NSI 189 phosphate powder
CAS No: 1270138-40-3
Mol.: C22H30N4O
Systematic (IUPAC) name
NSI-189
NSI189
NSI 189
Assay (by HPLC) : 99.21%
Appearance : White Crystalline powder
State of solution : Clear and colorless
Loss on drying : 0.25%
Iron : 7ppm
Application: For research used only
Batch Quantity: 8 KG
Packing: 1 kg/bag
Packing : Pack in two layers plastic-bag.
Storage Store in a well-closed place with constant low temperature and no direct sun light. Protect from moisture.
Conclusion: Cconform to in-house specification
NSI-189 is a benzylphiperizine-aminiopyridine, nootropic and neurogenic
research chemical created by Neuralstem, Inc. that was derived from
pyrazine and nicotinamide. Studies have shown that it stimulates
neurogenesis of human hippocampus-derived neural stem cells in vivo and
vitro. In healthy adult mice, NSI-189 has been shown to increase the
hippocampal volume by 20% and reverse behavioral symptoms in mouse
depression models, meaning at the source it could address depression.
Tests have shown that NSI-189 significantly improved behavioral
responses that are associated with depression . In humans it may counter
hippocampal atrophy which is seen in disorders such as MDD, reversing
their symptoms. A phase 1B randomized, double-blind, placebo-controlled,
multiple-dose escalation study conducted over a 28 day period showed
behavioral efficacy in 24 patients who were orally administered NSI-189 .
The efficacy measurements showed a clinically meaningful reduction in
cognitive and depressive symptoms across all measures, and appeared to
persist over time during follow up for the efficacy assessments which
included the Clinical Global Impression – Improvement (CGI-I),
Montgomery-Aserb Depression Rating Scale (MADRS), Cognitive and Physical
Functioning Questionnaire (CPFQ, and the Symptoms of Depression
Questionnaire (SDQ).
