WASHINGTON Wholesale Bayern Munich Jersey , April 23 (Xinhua) -- Electrical pulses delivered from cochlear implants, which have been commercially available since the 1970s, can be used to regrow auditory nerves in people with severe hearing loss, Australian researchers said Wednesday.
The research, published in the U.S. journal Science Translational Medicine Wholesale Barcelona Jersey , may also herald a possible new way of treating a range of neurological disorders, including Parkinson's disease, and psychiatric conditions such as depression through this novel way of delivering gene therapy.
"People with cochlear implants do well with understanding speech, but their perception of pitch can be poor, so they often miss out on the joy of music Wholesale Chelsea Jersey ," senior author Gary Housley, who is professor of the University of New South Wales, said in a statement.
"Ultimately, we hope that after further research, people who depend on cochlear implant devices will be able to enjoy a broader dynamic and tonal range of sound Wholesale Atletico Madrid Jersey , which is particularly important for our sense of the auditory world around us and for music appreciation," Housley said.
The five-year research focused on regenerating surviving nerves after age-related or environmental hearing loss, using existing cochlear technology, which can partially restore hearing by providing direct electrical stimulation to auditory nerves in the inner ear. However, current cochlear implants cannot restore hearing to normal Wholesale AS Roma Jersey , and the electrode design has changed little in decades.
According to the researchers, auditory nerve endings can regenerate if neurotrophins, a naturally occurring family of proteins crucial for the development, function and survival of neurons, are delivered to the auditory portion of the inner ear known as the cochlea.
But until now Wholesale Arsenal Jersey , research has stalled because safe, localized delivery of the neurotrophins can't be achieved using drug delivery, nor by viral-based gene therapy.
In the new study involving completely deaf guinea pigs, the researchers developed a way of using electrical pulses delivered from the cochlear implant to deliver a solution of DNA containing the brain-derived neurotrophic factor (BDNF) gene to the cells close to the array of implanted electrodes.
Within a few hours, cells in the cochlea took up the DNA and started to produce neurotrophins Wholesale AC Milan Jersey , they said.
The researchers tested the animals' hearing using the auditory brainstem response test, a common technique used to measure hearing in newborn babies.
They found that animals that were once completely deaf had their hearing restored to almost normal levels.
"No-one had tried to use the cochlear implant itself for gene therapy," said Housley. "With our technique, the cochlear implant can be very effective for this."
First author Jeremy Pinyon of the university said it's possible that in the future this gene delivery would only add a few minutes to the implant procedure.
Integration of this technology into other "bionic" devices such as electrode arrays used in deep brain stimulation for treating diseases like depression could also afford opportunities for safe, directed gene therapy of complex neurological disorders Wholesale Manchester United Jersey , the researchers said.
"Our work has implications far beyond hearing disorders," said co-author Matthias Klugmann, associate professor of the university.
"Gene therapy has been suggested as a treatment concept even for devastating neurological conditions and our technology provides a novel platform for safe and efficient gene transfer into tissues as delicate as the brain."
The process of auto transport would be very simple and straight forward if
you do it in the most proper and responsible way. The cost and time of the car
shipping would largely depend on the time and effort that you take to select the
auto transport company. There are many shipping companies out there and with the
help of internet it is easy to find and compare the different companies and
their services. But the main thing is that you need to ensure the reliability
and responsibility of the company before hiring them. It would be better to keep
certain guidelines in mind before entrusting your car in the hands of
strangers.
First step is to find the price that the car shipping company
offers. Each company would offer different prices for their services. Ask for a
free quote and see if the company gives you all services that you need in the
final price quoted. Next you have to check the payment options. Some companies
would ask for a payment upfront while others won't. So check if the company
needs advance payment. But if the company ask for complete payment upfront, then
it is better to avoid them as they would be a scam. It is important to
understand the payment options since that would help you to decide upon the
reliability of the company. This should be sought in every auto transport
company that you look for.
Now comes the most important part. It is
extremely vital to analyze the contract properly before signing the agreement.
Make sure that all the verbal agreements are taken in written format. If you
take this precaution, nothing can be manipulated later on the contract. So that
you would not be faced with unpleasant surprises and scuffles with the car
shipping company. Ensure that the estimated date of delivery for the vehicle is
in the contract. But it is better not to be obstinate about the date of delivery
that has been mentioned in the agreement. This is because none of the companies
can guarantee the exact delivery date since they would be transporting more than
one vehicle at a time.
The insurance coverage offered by the company is
yet another factor that needs to be analyzed. You must make sure that the
vehicle transporting company would provide insurance for your car. If any
damages happen during the transport Cheap
Real Madrid Jersey , the company is obliged to take care of them if
they are providing a proper insurance. The in. Cheap Womens
Jerseys Cheap Jerseys China
Wholesale Cheap Youth
Jerseys Cheap Soccer Shirts
China Cheap NHL
Shirts Cheap NBA
Hoodies Cheap MLB Jerseys
China Cheap Soccer Shirts Free
Shipping Cheap NFL Hats Free
Shipping Wholesale
Hoodies
